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what to do with和how to deal with的区别是意思不同、用法不同。what to do with意思是怎么做，用...做什么，how to do with意思是如何做。
扩展资料
例句：The government appears to be in a quandary about what to do with so many people.政府似乎陷入了左右为难的境地，不知道该拿这么多人怎么办。The play was terrible; half the actors didn't know what to do with their hands.这个剧演得糟极了，一半演员连手都不知怎么放。Both candidates have plans for how to do with it, Tom foreman compares their ideas.两位候选人都有如何处理赤字的计划，汤姆弗尔曼对比了他们的意见。
